Senior Scientist 1 Antibody Engineering & Biologics Design

Senior Scientist 1 Antibody Engineering & Biologics Design
Evotec
Macclesfield, United Kingdom

About the Role

We are seeking an experienced and highly motivated Senior Scientist 1 to join our Protein Sciences team and play a key role in the design and development of next-generation biologic therapeutics.
This is an exciting opportunity for a scientist with deep expertise in antibody engineering and biologics development to lead the design, expression, purification, and characterization of complex therapeutic molecules, including monoclonal antibodies, bispecific antibodies, multispecific formats, and other engineered protein therapeutics.
Working within multidisciplinary project teams, you will contribute scientific leadership across client-facing drug discovery programs, helping to translate innovative concepts into high-quality therapeutic candidates. You will have the opportunity to influence project strategy, drive scientific innovation, and collaborate with world-class experts across protein engineering, discovery biology, and drug development.

Key Responsibilities

Lead the design and execution of biologics discovery and engineering strategies across multiple client and internal projects.
Design, engineer, express, purify, and characterize complex biologics, including monoclonal antibodies, bispecific antibodies and other therapeutic biologics.
Develop and optimize expression systems and purification workflows to deliver high-quality proteins suitable for screening, characterization, and downstream development.
Drive experimental design and scientific decision-making through robust data analysis, interpretation, and communication of results.
Identify innovative approaches and emerging technologies to improve biologics discovery and development workflows.
Act as a biologics scientific lead on projects, coordinating activities across disciplines and ensuring delivery of key milestones.
Present scientific findings to internal stakeholders and external clients, providing clear recommendations and strategic guidance.
Contribute to scientific excellence through publications, conference presentations, and external collaborations where appropriate.
Mentor junior scientists and contribute to the development of technical capabilities within the team.
What We're Looking For
Essential
PhD in Molecular Biology, Protein Engineering, Biochemistry, Biotechnology, Immunology, or a related discipline.
Minimum 5 years of industrial and/or postdoctoral experience in antibody discovery, antibody engineering, or biologics development.
Extensive hands-on experience designing and developing therapeutic antibodies and complex biologic formats.
Strong expertise in recombinant biologics expression and purification technologies.
Experience developing and optimizing workflows for challenging and novel biologic molecules.
Demonstrated ability to design experiments, solve complex scientific problems, and make data-driven decisions.
Experience leading projects and collaborating effectively within cross-functional teams.
Excellent communication and presentation skills with the ability to engage both scientific and non-scientific stakeholders.
Desirable
Experience with bispecific, multispecific, TCR, fusion protein, or other advanced biologics formats.
Knowledge of developability assessment, molecular optimization, and protein characterization techniques.
Experience using computational biology, structural modelling, molecular design, or AI-enabled protein engineering tools.
Track record of publications, patents, conference presentations, or successful therapeutic candidate advancement.
Previous experience working in a CRO/CDMO or client-facing environment.
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Evotec