Results
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PhD Studentship: Living materials in nature: active matter, behaviour and bee nests
Self-organised systems in animals, such as the nests of social insects, have evolved to offer advantages that support survival across diverse habitats and climates. These nests represent…
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PhD Studentship: Integrative Analysis of ADHD Using Graph Kernels on UK Biobank Multimodal Data
Introduction Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder marked by inattention, hyperactivity, and impulsivity. Globally, it affects about 5% of…
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PhD Studentship: Arithmetic Moments and Random Matrix Statistics over Function Fields
The study of L-functions — their moments, zero statistics, and connections to random matrix theory — sits at the heart of modern analytic number theory. Function fields over finite fields…
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PhD Studentship: Cut and project schemes in hyperbolic space with applications to acoustic metamaterials
The discovery of quasicrystals – honoured with the 2011 Chemistry Nobel prize – has generated and continues to stimulate a tremendous amount of research in the international mathematics and…
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PhD Studentship: Cut and project schemes in hyperbolic space with applications to acoustic metamaterials
Alternative splicing enables a single gene to produce multiple mRNA isoforms, and potentially proteins with distinct functions. It is especially important in the brain, where transcript…
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PhD Studentship: Allele-resolved genetics and epigenetics in type 2 diabetes
Type 2 diabetes (T2D) affects over 800 million people worldwide. It is a complex disorder and an individual’s genetics influences disease risk. Understanding how DNA differences drive this…
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PhD Studentship: Decoding cellular diversity in the brain: functional annotation of neuronal subtypes across development and disease
The human brain contains an extraordinary diversity of cell types, each with distinct functions, molecular programmes and roles in disease. Even within neurons, numerous excitatory and…
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PhD Studentship: Decoding the rules of human gene interaction networks using combinatorial functional genomics
Large-scale sequencing initiatives have identified thousands of genetic variants associated with human traits and disease. However, understanding how these variants influence biology…
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PhD Studentship: Developing a variant effect predictor for multiple missense variants in the same protein molecule to aid clinical interpretation
Context: Genome sequencing is becoming increasingly widespread in both research and diagnostics, and over a million people have already had their genomes sequenced. However, interpreting…
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PhD Studentship: Dissecting Metabolic Heterogeneity in Severe Mental Illness Through Genetic Clustering and Single-Cell Functional Genomics
This PhD aims to understand why genetic liability to severe mental illness (SMI), particularly schizophrenia and bipolar disorder, is associated with different patterns of adiposity and…
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PhD Studentship: Functional genomic characterisation of genetic risk for diabetic neuropathy using human stem cell models
Around half of all people with diabetes develop peripheral neuropathy, its commonest complication worldwide. It begins with the loss of the smallest sensory nerve fibres, causing pain,…
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PhD Studentship: Functional genomics of health and unhealthy fat distribution
Where fat is stored in our bodies is a major determinant of health. Storing fat safely under the skin (subcutaneous fat) protects against metabolic disease like heart failure and type 2…
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PhD Studentship: Functional interpretation of human NF1 genetic variation using precision genome editing and in vivo phenotyping
Neurofibromatosis type 1 (NF1) is a genetic disorder that causes a range of symptoms and affects approximately 1 in 3,000 people. These include abnormalities in skin pigmentation, problems…
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PhD Studentship: In Silico Directed Evolution of Biological Qubits: Rational Design of Nanoscale Quantum Transducers
Engineered flavoproteins, LOV domains, and fluorescent proteins have recently demonstrated that radical pair mechanisms (RPM) can serve as biological qubits with optical readouts, achieving…
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PhD Studentship: Modelling coevolution in aquatic environments shaped by flow
Coevolution is the process of species evolving together and influencing each other’s evolutionary path. For a system of microbes and viruses, this entails an ongoing dynamic of the host…
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PhD Studentship: AI-Enabled Smart Spectroscopy Pixels: Revealing Microbial Responses to Antibiotics
Spectroscopy has long offered a powerful window into nature, revealing the hidden structure and dynamics of matter through its interaction with light. Extending this window to individual…
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PhD Studentship: Mapping and functional interrogation of mitochondrial DNA modifications in Parkinson’s disease
There is increasing evidence that the mitochondrial genome may be regulated by DNA modifications, but their extent, identity and functional importance remain unclear. This uncertainty…
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PhD Studentship: Next-generation machine learning for genetic interaction prediction with lab-in the-loop validation in pancreatic cancer
Background Cancer cells often depend on specific genes to survive, making those genes attractive drug targets. CRISPR screens knock out genes to measure their importance for cancer cell…
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PhD Studentship: One read, one cell: Decoding cell identity with long-read sequencing
Background What if we could resolve the epigenome of individual cell types from complex human tissues without ever having to physically separate the cells? The majority of…
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PhD Studentship: Quantifying compounding and cascading physical climate risk to UK infrastructure
Climate change is intensifying hazards, such as flooding, heat, drought, storms, that threaten the resilience of UK infrastructure. Most existing risk assessments treat these hazards in…